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Latest Articles on Influenza

  • In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection Thu, 13 May 2021 06:00:00 -0400
    We report that influenza A virus infection induces changes in odor traits that could be captured by real-time high-resolution mass spectrometry in a living mouse model. The most striking changes in the volatile metabolites may be associated mostly to glyoxylate/dicarboxylate metabolism.
  • To vaccinate or not to vaccinate; that is the question! (New insights on COVID-19 Vaccination) Thu, 13 May 2021 06:00:00 -0400
    CONCLUSIONS: During the COVID-19 pandemic, influenza vaccination is mandatory for all individuals provided no contraindications. Three SARS-CoV-2 vaccines are being released , while FDA approval for monoclonal antibodies for the treatment of at-risk outpatients to lower hospitalization rates is ongoing.
  • Research progress on active components and mechanism of Isatidis Radix for influenza virus Thu, 13 May 2021 06:00:00 -0400
    Isatidis Radix is the dried root of the Isatis indigotica, with pharmacological effects such as heat-clearing and detoxification, cooling blood and pharyngeal relief, antibacterial and anti-inflammatory effects. It is often used clinically to prevent and treat influenza and other diseases. In this paper, relevant domestic and foreign literatures in recent years were summarized, and it was found that Isatidis Radix lignans, indole alkaloids, polysaccharides, etc. were the main active components...
  • Thinking and practice of key links in design of clinical trial scheme for treatment of influenza with traditional Chinese medicine Thu, 13 May 2021 06:00:00 -0400
    To sort out the key points in "PICOS" design of clinical trial scheme for influenza, and optimize the clinical trial scheme of Chinese patent medicine in the treatment of influenza by strictly following the principle of evidence-based medicine, focusing on the clinical practice of the disease, and highlighting the characteristics of traditional Chinese medicine. "The design of a randomized, double-blind, positive parallel control study of a certain herbal preparation for the...
  • Asp149 and Asp152 in chicken and human ANP32A play an essential role in the interaction with influenza viral polymerase Thu, 13 May 2021 06:00:00 -0400
    The acidic nuclear phosphoprotein 32 family member A (ANP32A) is a cellular host factor that determines the host tropism of the viral polymerase (vPol) of avian influenza viruses (AIVs). Compared with human ANP32A (hANP32A), chicken ANP32A contains an additional 33 amino acid residues (176-208) duplicated from amino acid residues 149-175 (27 residues), suggesting that these residues could be involved in increasing vPol activity by strengthening interactions between ANP32A and vPol. However, the...
  • Protective effects of the NLRP3 inflammasome against infectious bursal disease virus replication in DF-1 cells Thu, 13 May 2021 06:00:00 -0400
    Inflammatory responses are an important part of the innate immune response during viral infection. Various inflammasome complexes have been identified. The pyrin domain-containing 3 (NLRP3) inflammasome plays a critical role in detecting some RNA viruses, such as influenza virus. However, the effect of the NLRP3 inflammasome on infectious bursal disease virus (IBDV) replication is still unclear. Here, we report that IBDV-infection induces the transcription of NLRP3 inflammasome and IL-1β genes...
  • Insect High FiveTM cell line development using site-specific flipase recombination technology Thu, 13 May 2021 06:00:00 -0400
    Insect Trichoplusia ni High FiveTM (Hi5) cells have been widely explored for production of heterologous proteins, traditionally mostly using the lytic baculovirus expression vector system (BEVS), and more recently using virus-free transient gene expression systems. Stable expression in such host cells would circumvent the drawbacks associated with both systems when it comes to scale-up and implementation of more efficient high-cell density process modes for the manufacturing of biologics. In...
  • Promoting Healthy Ageing in South Africa Through Vaccination of the Elderly Thu, 13 May 2021 06:00:00 -0400
    The World Health Organization estimates that globally, the proportion of people aged ≥60 years will more than double by the year 2050, with the majority of elderly people living in low- and middle-income countries such as South Africa. Population ageing is an impending public health concern, potentially negatively impacting on South Africa's economy and health system if the government does not adequately prepare for this change. Globally, many potential solutions to ensure healthy ageing are...
  • Barriers and Facilitators Associated With Vaccine Acceptance and Uptake Among Pregnant Women in High Income Countries: A Mini-Review Thu, 13 May 2021 06:00:00 -0400
    Vaccination during pregnancy is a safe and effective intervention to protect women from potentially severe consequences of influenza and reduce risk of influenza and pertussis in their infants. However, coverage remains variable. In this mini-review we update findings from a 2015 systematic review to describe results from recent studies in high income countries on the uptake of influenza and pertussis vaccination in pregnancy, reasons for vaccine hesitancy and barriers to increasing uptake, from...
  • Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells Thu, 13 May 2021 06:00:00 -0400
    Misfolding of the cellular prion protein, PrP^(C), into the amyloidogenic isoform, PrP^(Sc), which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases. No pathogens other than prions have been identified to induce misfolding of PrP^(C) into PrP^(Sc) and propagate infectious prions in infected cells. Here, we found that infection with a neurotropic influenza A virus strain (IAV/WSN) caused misfolding of PrP^(C) into PrP^(Sc) and generated...