- Constrained Optimization for Pneumococcal Vaccination in Brazil Tue, 13 Apr 2021 06:00:00 -0400
CONCLUSION: The study shows that with 4 constraints on budget, time horizon, vaccine coverage, and cost efficiency, a CO analysis could identify the most cost-efficient overall pneumococcal vaccination strategy for Brazil, allowing for limited vaccine budget increase while obtaining appropriate health gain.
- Prospective assessment of smell and taste impairment in a South-American coronavirus disease 2019 (COVID-19) cohort: Association with the need for hospitalization and reversibility of dysfunction Tue, 13 Apr 2021 06:00:00 -0400
- Influenza vaccination uptake and factors influencing vaccination decision among patients with chronic kidney or liver disease Tue, 13 Apr 2021 06:00:00 -0400
CONCLUSION: While influenza vaccination willingness in patients with CKLD is increasing in the 2020/2021 season, vaccination rates may still remain <50%. Novel co-operations with primary health care, active vaccination surveillance and financial reimbursement may substantially improve vaccination rates in high-risk CKLD patients.
- Influenza Antiviral Subversion: Now the Host is in on the Act Tue, 13 Apr 2021 06:00:00 -0400
- Is Viral Coinfection A Risk Factor For Severe Lower Respiratory Tract Infection? A Retrospective Observational Study Tue, 13 Apr 2021 06:00:00 -0400
CONCLUSION: Children with viral coinfection, particularly with rhinovirus, RSV, influenza-A, PIV3, and bocavirus, may be followed closely regarding the clinical changes. This article is protected by copyright. All rights reserved.
- Metabolic and functional impairment of CD8(+) T cells from the lungs of influenza-infected obese mice Tue, 13 Apr 2021 06:00:00 -0400
Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pulmonary CD8^(+) T cell metabolism, cytokine production, and transcriptome as a potential mechanism of impairment during influenza virus infection in mice. Male C57BL/6J lean and obese mice were infected with sub-lethal mouse-adapted A/PR/8/34...
- The role of host cell Rab GTPases in influenza A virus infections Tue, 13 Apr 2021 06:00:00 -0400
Influenza A virus (IAV) is a crucial cause of respiratory infections in humans worldwide. Therefore, studies should clarify adaptation mechanisms of IAV and critical factors of the viral pathogenesis in human hosts. GTPases of the Rab family are the largest branch of the Ras-like small GTPase superfamily, and they regulate almost every step during vesicle-mediated trafficking. Evidence has shown that Rab proteins participate in the lifecycle of IAV. In this mini-review, we outline the regulatory...
- SARS-CoV-2 spike E484K mutation reduces antibody neutralisation Tue, 13 Apr 2021 06:00:00 -0400
- Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling Tue, 13 Apr 2021 06:00:00 -0400
The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. However, the potential involvement of RNA sensors in DNA repair is unknown. Here, we found that retinoic acid-inducible gene I (RIG-I), a key cytosolic RNA sensor that recognizes RNA virus and initiates the MAVS-IRF3-type I IFN signaling cascade, is recruited to double-stranded breaks (DSBs) and suppresses non-homologous end joining (NHEJ). Mechanistically, RIG-I interacts with XRCC4, and...
- Attitudes towards influenza and uptake of the flu vaccine: A survey of pharmacy staff working in English hospitals Tue, 13 Apr 2021 06:00:00 -0400
CONCLUSIONS: This is the first survey to focus on vaccine behaviours of all pharmacy staff groups working in hospitals. Current uptake of the influenza vaccine may be increased through engagement of senior pharmacy colleagues and providing education on influenza, vaccines, and vaccination. Similar studies should be undertaken on a larger scale to fully interrogate the differences between pharmacy staff groups.