Latest Articles on Influenza
- SARS-CoV-2 infections in professional orchestra and choir musicians-a prospective cohort study Thu, 29 Sep 2022 06:00:00 -0400
During the COVID-19 pandemic, rehearsal and concert activities of professional orchestras and choirs were severely restricted based on the assumption of particularly high infection risks associated with wind instruments and singing. Therefore, our primary objective was to determine the incidence of SARS-CoV-2 infections in orchestra and choir musicians compared to controls. We also assessed influenza, flu, upper respiratory tract infections, and course of illness. Musicians from professional... - Recent Developments in Single-Virus Fusion Assay Thu, 29 Sep 2022 06:00:00 -0400
Viral infection is a global health hazard. A crucial step in the infection cycle of enveloped viruses is the fusion of viral and host cellular membranes, which permits the transfer of the viral genome to the host cells. Membrane fusion is a ubiquitous process involved in sperm-egg fusion, exocytosis, vesicular trafficking, and viral entry to host cells. While different protein machineries catalyze the diverse fusion processes, the essential step, i.e., merging of two lipid bilayers against a... - The importance of viruses in ventilator-associated pneumonia Thu, 29 Sep 2022 06:00:00 -0400
CONCLUSION: Although infrequent, a range of viruses may cause VAP. Viruses more often complicate SCT and immunosuppression, but one can isolate viruses in immunocompetent subjects. Viral VAP produces severe infection and results in high mortality rates. Clinical features do not differentiate viral from nonviral VAP. - Etiologies of outpatient medically attended acute respiratory infections among young Ecuadorian children prior to the start of the 2020 SARS-CoV-2 pandemic Thu, 29 Sep 2022 06:00:00 -0400
CONCLUSIONS: Ongoing regional surveillance studies are necessary to optimize available and emerging pathogen-specific preventative measures. - Omicron Subvariants: Clinical, Laboratory, and Cell Culture Characterization Thu, 29 Sep 2022 06:00:00 -0400
CONCLUSIONS: Omicron subvariants continue to associate with a relatively high positivity and admissions. The BA.5 infections are more while BA.2 infections are less likely to have infectious virus, suggesting potential differences in infectibility during the Omicron waves. - Airway pathogens detected in stable and exacerbated COPD in patients in Asia-Pacific Thu, 29 Sep 2022 06:00:00 -0400
CONCLUSION: In patients with COPD in the Asia-Pacific region, the presence of Hi, Mcat or HRV in sputum samples significantly increased the odds of an exacerbation, providing further evidence of potential roles in triggering AECOPD. - Burden of influenza hospitalization among high-risk groups in the United States Wed, 28 Sep 2022 06:00:00 -0400
CONCLUSIONS: The risk of influenza-related complications is elevated in the elderly, especially those with certain underlying comorbidities, leading to excess healthcare resource utilization. Continued efforts, beyond currently available vaccines, are needed to reduce influenza burden in high-risk populations. - Pneumococcal vaccination coverage in individuals (16-59 years) with a newly diagnosed risk condition in Germany Wed, 28 Sep 2022 06:00:00 -0400
CONCLUSION: Despite recommendations from STIKO, pneumococcal vaccination coverage remains very low and with long delays in vulnerable individuals aged 16-59 in Germany. Further efforts are required to increase immunization levels and shorten time to vaccination among individuals 16-59 years of age developing conditions with higher susceptibility to pneumococcal infection. - Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model Wed, 28 Sep 2022 06:00:00 -0400
Influenza antivirals are important tools in our fight against annual influenza epidemics and future influenza pandemics. Combinations of antivirals may reduce the likelihood of drug resistance and improve clinical outcomes. Previously, two hospitalised immunocompromised influenza patients, who received a combination of a neuraminidase inhibitor and baloxavir marboxil, shed influenza viruses resistant to both drugs. Here-in, the replicative fitness of one of these A(H1N1)pdm09 virus isolates with... - The evolutionary footprint of influenza A subtype H3N2 strains in Bangladesh: implication of vaccine strain selection Wed, 28 Sep 2022 06:00:00 -0400
In February each year, World Health Organization (WHO) recommends candidate vaccine viruses for the forthcoming northern hemisphere (NH) season; however, the influenza season in the temperate zone of NH begins in October. During egg- or cell culture-propagation, the vaccine viruses become too old to confer the highest match with the latest strains, impacting vaccine effectiveness. Therefore, an alternative strategy like mRNA-based vaccine using the most recent strains should be considered. We...